Malaria is a mosquito-borne Infectious disease in Far Cry 2.

Malaria plays a major role in single-player Far Cry 2.

The player character becomes infected with malaria towards the end of the driving intro. The character will look at his hands and start coughing as the screen takes on a yellowish tint. At the end of the intro, the character will fall forward in the car and pass out as the driver says he looks tired.

The player will get malaria attacks every 30-40 real-life minutes. When one happens, the screen will take on a yellowish tint, and everything becomes blurry. In addition, the player is momentarily unable to sprint or jump until the yellow fades. If he chooses to not take a dose of medicine, he will have 2 or 3 more attacks. If the player still has medicine, on the final attack, the character will fall to the ground and become immobile until he takes a pill. If he has run out of pills, then the character will open up his empty bottle, stare at it in disbelief, then pass out, only to wake up in the church in Pala or the medical clinic in the Southern territory. During or after the attack, the player can take a pill to relieve the symptoms temporarily. The player can choose to hold off from taking any medicine right away, but he must take it before he can use syrettes.

It is possible, and necessary, to get more medicine after the tutorial. To do so, the player must talk to the priest in Pala when he is out of medicine. The priest says the player looks sick and then hands him passports and direct him to a general store or other building somewhere on the map. These buildings will always be under attack from militia when the player arrives. Once he has cleared the area, he can trade the passports for more medicine.

The same must be done in the Southern territory, the first time at the medical clinic in the main town. The player must, however, first complete a few missions in the south before the doctor will talk to him about medicine.

Every bottle of medicine only has 3 or 4 doses in it. Should the character pass out from a malaria attack and wake in the church or clinic, he will have one dose of medicine.

There is a glitch where if the player does not start the main missions and rather starts the side-missions, there will be an infinite supply of malaria pills until he begins the main missions.

Malaria attacks can happen at any area, no matter what the player is doing, even during combat or while driving. It makes driving harder and in combat you are vulnerable, which is deadly if you also have low health, ammunition or both.